Somatic mutation as an explanation for epigenetic aging
Zane Koch, Adam Li, Daniel S. Evans…·Trey E. Ideker
The paper shows that somatic mutations correlate with methylation changes and can predict age similarly to epigenetic clocks.
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Harvard UniversityORCID 0000-0001-5075-5194Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Zane Koch, Adam Li, Daniel S. Evans…·Trey E. Ideker
The paper shows that somatic mutations correlate with methylation changes and can predict age similarly to epigenetic clocks.
Adam Li, Alice E. Kane, Amber L. Mueller…·David A. Sinclair
This paper develops novel feature selection methods to construct epigenetic clocks with high accuracy using fewer CpG sites, outperforming existing models.
Kevin Bradley Dsouza, Adam Li, Vijay K. Bhargava, Maxwell W. Libbrecht
This paper introduces Epi-LSTM, a deep LSTM autoencoder that creates a pan-celltype epigenomic representation, outperforming existing methods in most cell types and providing smoother genomic representations.