Christopher Carlein

This study develops a scalable method to produce high-purity stem cell-derived β-cells that closely mimic human islets in function and transcriptional profile.

The paper investigates how defective cardiolipin remodeling in Barth Syndrome affects pancreatic islet function and metabolism, finding improved glucose tolerance and compensatory metabolic adaptations in a mouse model.

This paper develops a multichannel microendoscope for in-organ cellular imaging, achieving subcellular resolution and enabling functional studies in various tissues.