Grant Kemp

This study shows that buried ion-pairs in artificial proteins reshape folding pathways by introducing kinetic barriers that are overcome by hydrophobic collapse and core packing.

This study uses Force Profile Analysis to examine cotranslational folding of alkaline phosphatase in E. coli periplasm, revealing folding forces transmitted from periplasm to ribosome and identifying disulfide-stabilized intermediates.

The paper compares FPA with other techniques to study cotranslational folding of two protein domains, finding they identify similar folding transitions.