Alexander Jussupow

This study shows that buried ion-pairs in artificial proteins reshape folding pathways by introducing kinetic barriers that are overcome by hydrophobic collapse and core packing.

aSAM, a latent diffusion model trained on molecular dynamics, generates heavy-atom protein ensembles; its temperature-conditioned variant aSAMt reproduces mdCATH thermal unfolding and extrapolates beyond training temperatures.

The paper studies non-native cargo loading into HO shell variants and finds that activity depends on cargo amount, not shell permeability, with simpler variants showing robust assembly.

The paper uses SAXS and PDDF to analyze BMC shell structures and enzyme encapsulation in Haliangium ochraceum BMCs expressed in E. coli, showing cytoplasmic protein capture during assembly.

COCOMO2 is a coarse-grained model that extends to folded proteins, enabling realistic simulations of biomolecular interactions and phase separation.

This study shows that mitochondrial supercomplex formation reduces membrane strain and enhances allosteric crosstalk, with implications for OXPHOS efficiency.

This study reveals how hnRNP A1 binds to the terminal loop of pri-mir-18a, destabilizing stem base-pairing to enhance miRNA processing.