Author

Guillermo A. Orsi

Centre National de la Recherche ScientifiqueORCID 0000-0001-5139-1417Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Biophysics· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 2 Organism:Drosophila· 2 Research Focus:gene regulatory network inference· 2 Research Focus:spatial domain detection· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Béatrice HorardiD· 2 shared Benjamin LoppiniD· 2 shared Daniela Torres-CampanaiD· 2 shared Gérard BenoitiD· 2 shared Agnès DumontiD· 1 shared Arthur Argoud· 1 shared Aurèle PiazzaiD· 1 shared Bassam HajjiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersGenetics

Béatrice HorardORCID

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4 papers

Recent·Most cited

Developmental BiologybioRxivPreprintOct 16, 2026

Genome-wide chromatin reset at the onset of leg regeneration in pancrustaceans

Maëlle Louvier, Gillian Forbes, Mahmood Mohammed-Ali…·Guillermo A. Orsi

The paper investigates chromatin state reorganization during leg regeneration in pancrustaceans, finding a conserved sequence of chromatin resetting and pioneer factor activation across species.

DOI 10.64898/2026.10.09.757970

ChIP-seqbulk RNA-seq

𝕏 PostBluesky

BiophysicsbioRxivPreprintNov 19, 2025

Polarization MultiFocus Microscopy for volumetric super-resolution and orientation imaging of biofilaments

Louise Régnier, Caio Vaz Rimoli, Simli Dey…·Bassam Hajj

This paper introduces PolMFM, a method for simultaneous 3D localization and orientation imaging of single molecules, validated on actin filaments and chromatin in crickets.

2 citations

zebrafishchicken / avian

𝕏 PostBluesky

GeneticsPLoS GeneticsPeer-reviewedJan 4, 2022

Three classes of epigenomic regulators converge to hyperactivate the essential maternal gene deadhead within a heterochromatin mini-domain.

Daniela Torres-Campana, Béatrice Horard, Sandrine Denaud…·Guillermo A. Orsi

The paper identifies four chromatin regulators that hyperactivate the maternal gene deadhead within a repressive heterochromatin mini-domain in Drosophila.

6 citations

DrosophilaChIP-seq

𝕏 PostBluesky

GeneticsPLoS GeneticsPeer-reviewedMar 5, 2020

The Lid/KDM5 histone demethylase complex activates a critical effector of the oocyte-to-zygote transition

Daniela Torres-Campana, Shuhei Kimura, Guillermo A. Orsi…·Benjamin Loppin

The paper identifies Lid/KDM5 and Sin3A-HDAC1 as essential for zygote formation in Drosophila by regulating transcriptional activation of dhd.

11 citations

Drosophilaexperimental assay

𝕏 PostBluesky