Author

Parik Kakani

Indian Institute of Science Education and Research, BhopalORCID 0000-0001-5142-7774Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:DNA methylation· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

Sanjeev ShuklaiD· 4 shared Atul Samaiya· 3 shared Deepak PantiD· 2 shared Rushikesh Joshi· 2 shared Shruti Ganesh DhamdhereiD· 2 shared Abhisek Brahma· 1 shared Abhisek Panda· 1 shared Abin Sabu· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersCancer Biology

Sanjeev ShuklaORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 29, 2026

A CTCF-LDHB axis converts nuclear lactate availability into an H3K18 acylation switch that directs alternative splicing in hypoxic breast cancer

Parik Kakani, Abhisek Brahma, B Jithin…·Sanjeev Shukla

DOI 10.64898/2026.10.27.762200

humanproteomics

Cancer BiologyPLoS BiologyPeer-reviewedOct 28, 2025

PRMT5-mediated histone methylation regulates alternative splicing via MECP2-PTBP1 to promote EMT in breast cancer hypoxia

Srinivas Abhishek Mutnuru, Pooja Yadav, Parik Kakani…·Sanjeev Shukla

7 citations

humanDNA methylation

Cancer BiologyeLifePeer-reviewedAug 14, 2025

Interplay of YEATS2 and GCDH regulates histone crotonylation and drives EMT in head and neck cancer

Deepak Pant, Parik Kakani, Rushikesh Joshi…·Sanjeev Shukla

This study identifies a novel mechanism where YEATS2 and GCDH regulate histone crotonylation, promoting EMT in head and neck cancer.

DOI 10.7554/elife.103321.3

Molecular BiologyCell ReportsPeer-reviewedFeb 1, 2025

Hypoxia-induced CTCF mediates alternative splicing via coupling chromatin looping and RNA Pol II pause to promote EMT in breast cancer

Parik Kakani, Shruti Ganesh Dhamdhere, Deepak Pant…·Sanjeev Shukla

This study shows hypoxia-induced CTCF promotes EMT in breast cancer by regulating alternative splicing through chromatin looping and RNA Pol II pausing.

12 citations

humanbulk RNA-seq