A. V. Smirnov

The paper investigates how condensins shape chromatin contacts in interphase nuclei using Hi-C data from mouse embryonic stem cells, showing structural memory of mitotic folding.

The paper characterizes a CAG-ACE2 transgenic mouse model for SARS-CoV-2 infection using Cas9-enhanced Nanopore sequencing to analyze transgene integration.

The paper deletes TAD boundaries at the Kit locus in mice and shows that this causes tissue-specific ectopic activation of a neighboring gene in melanocytes, leading to lighter coloration.

The paper evaluates two AID systems for chromatin protein degradation in mammalian cells, finding that AtAFB2 is more efficient and robust than OsTIR1 with proper puromycin selection.

The paper uses DNA barcoding to show that homologous recombination, specifically SDSA and DSBR, predominantly processes injected transgenes in mouse zygotes, with over 80% of copies undergoing recombination.