Alexey N. Korablev

Pcbp1 orchestrates amino acid metabolism burst during the naive-to-primed pluripotency transition

This study identifies Pcbp1's role in enhancing amino acid metabolism during the naive-to-primed pluripotency transition, linking its deficiency to embryo growth arrest and reduced protein synthesis.

Direction and modality of transcription changes caused by TAD boundary disruption in Slc29a3/Unc5b locus depends on tissue-specific epigenetic context

The paper shows that disrupting TAD boundaries in the Slc29a3/Unc5b locus causes tissue-specific transcriptional changes in multiple genes.

TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene

The paper deletes TAD boundaries at the Kit locus in mice and shows that this causes tissue-specific ectopic activation of a neighboring gene in melanocytes, leading to lighter coloration.

DNA barcoding reveals that injected transgenes are predominantly processed by homologous recombination in mouse zygote

The paper uses DNA barcoding to show that homologous recombination, specifically SDSA and DSBR, predominantly processes injected transgenes in mouse zygotes, with over 80% of copies undergoing recombination.