Andrew R. Hesketh

This study investigates the cold-shock response in Streptomyces coelicolor A3(2) using RNA-seq and polysome profiling, identifying key genes and regulatory mechanisms involved in metabolic reprogramming and translational control.

This study identifies PNUTS-PP1 as a regulator of Cdk11 phosphorylation, showing that dephosphorylation by PNUTS-PP1 modulates Cdk11 activity and affects mRNA processing and splicing.

This study investigates how glucocorticoids modulate RNA binding proteins ZFP36L1 and ZFP36L2, showing their role in transcriptional and post-transcriptional gene regulation through subcellular RNA binding and localization changes.

The paper constructs a synthetic yeast chromosome XI and demonstrates how non-coding DNA modifications affect cell fitness, enabling on-demand extrachromosomal circular DNA formation.

This study compares the effects of vitamin D2 and D3 on gene expression in rat oligodendrocyte precursor cells during differentiation, finding distinct gene expression changes associated with each form.

The paper investigates transcriptional and translational changes in Streptomyces coelicolor under heat stress, revealing significant translational control and novel stress response mechanisms.