Colin P. Sambrook Smith

Global analysis of the cold-shock response in the model antibiotic producing actinomycete, Streptomyces coelicolor A3(2)

This study investigates the cold-shock response in Streptomyces coelicolor A3(2) using RNA-seq and polysome profiling, identifying key genes and regulatory mechanisms involved in metabolic reprogramming and translational control.

The RNA binding proteins ZFP36L1 and ZFP36L2 modulate transcriptional and post-transcriptional genome-wide effects of glucocorticoids

This study investigates how glucocorticoids modulate RNA binding proteins ZFP36L1 and ZFP36L2, showing their role in transcriptional and post-transcriptional gene regulation through subcellular RNA binding and localization changes.

Vitamins D3 and D2 have marked but different global effects on gene expression in a rat oligodendrocyte precursor cell line

This study compares the effects of vitamin D2 and D3 on gene expression in rat oligodendrocyte precursor cells during differentiation, finding distinct gene expression changes associated with each form.

Genome-wide analysis of the role of the antibiotic biosynthesis regulator AbsA2 in Streptomyces coelicolor A3(2)

The paper investigates the role of AbsA2 in antibiotic biosynthesis in Streptomyces coelicolor by analyzing gene expression and DNA-binding sites in a deletion mutant.

PGP-UK: a research and citizen science hybrid project in support of personalized medicine

PGP-UK explores citizen science in genomics by recruiting participants, sharing data, and developing tools to advance personalized medicine.

Translational control plays an important role in the adaptive heat-shock response of Streptomyces coelicolor

The paper investigates transcriptional and translational changes in Streptomyces coelicolor under heat stress, revealing significant translational control and novel stress response mechanisms.