Xinyu Lu

The paper demonstrates iterative SCRaMbLE to optimize synthetic genome modules and chromosomes in yeast by selecting for improved growth phenotypes.

The paper introduces POLAR-seq, a low-cost method to analyze combinatorial genetic libraries by sequencing long amplicons to identify genotype-phenotype relationships in yeast.

The paper demonstrates the design of synthetic genome modules for programmable silencing in yeast using dCreSIR, a system that controls gene expression through loxPsym sites.

The paper constructs a synthetic yeast chromosome XI and demonstrates how non-coding DNA modifications affect cell fitness, enabling on-demand extrachromosomal circular DNA formation.