Wei Qing Xu

The paper profiles chromatin accessibility dynamics in zebrafish embryos using single-cell ATAC-seq to identify enhancers and transcription factor motifs involved in early cell fate decisions.

ISSAAC-seq jointly profiles chromatin accessibility and gene expression in single nuclei, revealing cell types, regulatory elements, and chromatin dynamics in mouse cerebral cortex.

This study investigates how dynamic histone regulations control noise in gene expression by showing that a positive feedback loop between transcriptional activators and histone acetyltransferases generates epigenetic bistability, leading to large noise, which can be reduced by modulating activator binding.