Dong Liu

Mechanistic insights into coronavirus inhibition by a distinct base-modified adenosine analog targeting the viral polymerase

This paper investigates the mechanism of 6-ethyl-modified 7-deazaadenosine (EDA) as a coronavirus inhibitor, showing it stalls viral polymerase without causing mutagenesis.

HSD17B7 is required for the function of sensory hair cells by regulating cholesterol synthesis

This study identifies HSD17B7 as critical for sensory hair cell function by regulating cholesterol synthesis, showing its role in auditory physiology and hearing loss.

High glucose treatment induced nuclei aggregation of microvascular endothelial cells via foxo1a-klf2a pathway

This study shows high glucose causes endothelial cell nuclei aggregation in zebrafish via foxo1a-klf2a pathway, linking it to microvascular complications.

Monocytes-derived cxcl12 guides a directional migration of blood vessels in zebrafish

The paper identifies Cxcl12a as a signaling molecule guiding long-distance vascular migration in zebrafish pectoral fins through monocyte-derived cues.

Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity

This study creates novel hybrid aminoglycoside antibiotics by swapping glycosyltransferases between gentamicin and kanamycin producers, resulting in compounds with potent activity and reduced ototoxicity.

The chromatin accessibility dynamics during cell fate specifications in zebrafish early embryogenesis

The paper profiles chromatin accessibility dynamics in zebrafish embryos using single-cell ATAC-seq to identify enhancers and transcription factor motifs involved in early cell fate decisions.

Light-controlled phosphorylation in the TrkA-Y785 site by photosensitive UAAs activates the MAPK/ERK signaling pathway

This paper tests a light-controlled phosphorylation method at the TrkA-Y785 site to study its effect on the MAPK/ERK signaling pathway.

De novo assembly of trachidermus fasciatus genome by nanopore sequencing

This study presents the first high-quality chromosome-level genome assembly of Trachidermus fasciatus using nanopore, Illumina, and Hi-C sequencing.

Blood vessels regulate primary motor neuronal pathfinding in zebrafish via exosome contained microRNA-22

This study shows that miRNA-22a in blood vessels guides motor neuron pathfinding in zebrafish via exosomes and regulates vascular and neuronal patterning.

Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity

The paper identifies and engineers a compact SlugCas9 variant with broad targeting range, high specificity, and activity for genome editing.

In-depth analysis reveals complex molecular etiology of idiopathic cerebral palsy

This study identifies molecular risk factors and mechanisms in idiopathic cerebral palsy through clinical and molecular analysis of 120 families.

THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis

This study identifies a THOC1 variant causing late-onset nonsyndromic hearing loss via p53-mediated hair cell apoptosis in zebrafish.

MECP2 duplication and mutations impair NSCs differentiation via miR-197 regulated ADAM10

This study shows that MECP2 duplication and mutations impair neural stem cell differentiation through miR-197 regulation of ADAM10 and NOTCH signaling.

Insm1a regulates motor neuron development in zebrafish

This study identifies Insm1a as a critical regulator of motor neuron development in zebrafish, showing it modulates olig2 and nkx6.1 expression to affect neuronal differentiation and function.