The IFN I response in tumor cells is shaped by PARP7-p300/CBP interactions through distinct loss- and gain-of-function mechanisms
Ivan Rodriguez Siordia, Sonja Rieth, Rory K. Morgan, Devon Jeltema, Jonathan Tullis, Jan Orth, Nan Yan, Andreas Marx, Michael Cohen
This paper identifies p300 and CBP as PARP7 substrates that regulate IFNβ through loss- and gain-of-function mechanisms in colorectal cancer cells.
bioRxiv · Jun 30, 2025 · PreprintCancer Biology