Jorge A. Castorena‐Gonzalez

This study shows that cholesterol depletion with cyclodextrins improves lymphatic vessel contractility in mice, suggesting a potential therapeutic strategy for lymphedema.

This study shows GLP-1R agonism directly improves lymphatic pumping capacity in mice through vasodilation and enhanced contractile function, independent of systemic weight loss effects.

This study identifies a Gαq/11-IP3R1-ANO1 signaling axis responsible for pressure-induced lymphatic contractions in mouse popliteal vessels.

This study identifies TRPV4-expressing macrophages as regulators of lymphatic vessel function through TXA2 receptors, suggesting therapeutic targets for lymphedema.