Tretinoin, a Vitamin A derivative, exerts antiviral effects against Chikungunya virus infection through the nuclear retinoid receptor signaling pathways
Soumyajit Ghosh, Chandan Mahish, Archana Mahapatra, Tathagata Mukherjee, Pratima Kumari, Bijita Bhowmick, Saikat De, Udvas Ghorai, Rajshree Rajmohan Jena, Seema Pradhan, Subhasis Chattopadhyay, Soma Chattopadhyay
This study shows that Tretinoin inhibits Chikungunya virus infection in vitro, in vivo, and ex vivo by modulating retinoic acid receptor signaling and reducing inflammation.
bioRxiv · Sep 29, 2025 · PreprintMicrobiology