Soma Chattopadhyay

Inhibition of JEV infection using β-Catenin specific inhibitor, iCRT-14

This study shows that inhibiting β-catenin with iCRT-14 reduces JEV replication in cell lines by modulating key pathway components and viral proteins.

Neuropilin-1 functions as a proviral and immunoregulatory host factor during Chikungunya virus infection

This study identifies Neuropilin-1 as a host factor that promotes Chikungunya virus infection while restraining proinflammatory cytokine production, and shows its inhibition reduces viral infection in vitro and in vivo.

Tretinoin, a Vitamin A derivative, exerts antiviral effects against Chikungunya virus infection through the nuclear retinoid receptor signaling pathways

This study shows that Tretinoin inhibits Chikungunya virus infection in vitro, in vivo, and ex vivo by modulating retinoic acid receptor signaling and reducing inflammation.

Telmisartan impedes JEV infection predominately via AT1/PPARγ axis

This study shows Telmisartan reduces JEV infection in vitro and in vivo by targeting the AT1/PPARγ axis, with significant anti-inflammatory effects.

Chikungunya virus susceptibility increases in the absence of mk2b and mk3 genes in zebrafish model

This study shows that zebrafish lacking mk2b or mk3 genes are more susceptible to Chikungunya virus infection, with mk3-/- showing the highest susceptibility, while double knockout shows reduced susceptibility.

Repurposing efavirenz, the HIV antiretroviral drug for Chikungunya virus infection.

This study identifies efavirenz's anti-CHIKV activity and shows it inhibits viral replication by targeting minus-sense RNA synthesis, suggesting its repurposing for antiviral therapy.

SARS-CoV2 genome analysis of Indian isolates and molecular modelling of D614G mutated spike protein with TMPRSS2 depicted its enhanced interaction and virus infectivity

The paper analyzes SARS-CoV-2 genome sequences from Indian isolates, identifies clade distribution and transmission routes, and shows the D614G mutation enhances spike protein interaction with TMPRSS2, increasing viral infectivity.