R-spondins are BMP receptor antagonists in early embryonic development
Hye-Yoon Lee, Carina Seidl, Rui Sun, Andrey Glinka, Christof Niehrs
This study identifies R-spondins as BMP receptor antagonists, showing they inhibit BMP signaling via ZNRF3 and regulate dorsoventral axis formation in Xenopus embryos.
Nature Communications · Nov 4, 2020Peer-reviewedDevelopmental Biology