Developmental BiologybioRxivPreprint
A ubiquitin-based mechanism for the oligogenic inheritance of heterotaxy and heart defects
Jennifer H. Kong, Cullen B. Young, Ganesh Varma Pusapati…·Rajat Rohatgi
This study identifies a ubiquitin-based genetic mechanism linking Megf8 and Mgrn1 mutations to congenital heart defects and heterotaxy through altered Hedgehog signaling.
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