Guoqiang Li

SnapHiC identifies high-resolution chromatin loops from scHi-C data and demonstrates cell-type-specific chromatin architecture in mouse and human cells.

The paper introduces Methyl-HiC, a method that simultaneously profiles DNA methylation and chromatin architecture, revealing coordinated methylation and dynamic chromatin contacts in mouse embryonic stem cells.

The paper introduces a method combining proximity ligation with chromatin immunoprecipitation and sequencing to map long-range chromatin interactions in eukaryotic cells, showing improved sensitivity and accuracy in mouse embryonic stem cells.