Lindsay Lee

The paper integrates 4D Nucleome data to analyze 3D genome structure and function in human cells, revealing chromatin domains, loops, and interactions, and showing how genetic variants affect genome folding.

The paper maps chromatin interactions in mouse fetal tissues and links them to gene expression and disease risk variants in humans.

SnapFISH identifies chromatin loops from multiplexed DNA FISH data with high sensitivity and accuracy in mouse embryonic stem cells.

SnapHiC-D identifies differential chromatin contacts between two scHi-C datasets with high sensitivity and accuracy, showing correlation with cell-type-specific gene expression and epigenomic features.

CRISPRpath enables parallel characterization of cis-regulatory elements for multiple genes in a pathway, identifying functional enhancers and distinguishing their impact on gene expression.

SnapHiC identifies high-resolution chromatin loops from scHi-C data and demonstrates cell-type-specific chromatin architecture in mouse and human cells.