Second-site capsule-locus mutations, not Ade efflux disruption, determine phage susceptibility across an Acinetobacter baumannii transposon mutant panel
Anita Tarasenko, Bhavya Papudeshi, Abbey L,K Hutton…·Robert A Edwards
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Flinders UniversityORCID 0000-0001-5359-3100Unclaimed ORCID profile · follow to get notified of new preprints
11 papers
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Anita Tarasenko, Bhavya Papudeshi, Abbey L,K Hutton…·Robert A Edwards
A.B. Tarasenko, Bhavya Nalagampalli Papudeshi, Van Nguyen…·Robert Alan Edwards
The paper shows bacterial strain identity is the main factor determining phage infectivity in Achromobacter, with lineage and strain identity explaining 90% of variation in infection efficiency.
Vijini Mallawaarachchi, George Spyro Bouras, Ryan R. Wick…·Robert Alan Edwards
agtools provides a Python framework to manipulate assembly graphs across formats, enabling analysis and integration into bioinformatics workflows.
George Spyro Bouras, Susanna R. Grigson, Milot Mirdita…·Robert Alan Edwards
Phold pairs ProstT5-predicted 3Di tokens with Foldseek searches against 1,363,704 curated phage structures, annotating 49.4% of CDS in 1,419 INPHARED genomes versus 34.7% for Pharokka MMseqs2.
Susanna R. Grigson, George Spyro Bouras, Bhavya Nalagampalli Papudeshi…·Robert Alan Edwards
Phynteny combines ESM2 protein embeddings, a BiLSTM, and circular-attention transformer layers to exploit phage gene order, assigning one of nine PHROG functional categories to unannotated genes.
Bhavya Nalagampalli Papudeshi, Michael J. Roach, Vijini Mallawaarachchi…·Robert Alan Edwards
Sphae is a bioinformatics pipeline that rapidly assesses phage therapeutic potential by analyzing genomic markers for safety and efficacy in under ten minutes.
George Spyro Bouras, Ghais Houtak, Ryan R. Wick…·Sarah Vreugde
Hybracter improves bacterial genome assembly accuracy and speed, outperforming existing tools in hybrid and long-read-only modes, especially for small plasmids.
Asha Z. Goodman, Bhavya Nalagampalli Papudeshi, Maria Mora…·Elizabeth Ann Dinsdale
This study shows that elasmobranch sharks have species-specific epidermal microbiomes influenced by denticle morphology and phylogeny.
Vijini Mallawaarachchi, Michael J. Roach, Przemysław Decewicz…·Robert Alan Edwards
Phables improves phage genome recovery from fragmented viral metagenome assemblies, recovering more high-quality genomes and resolving variants with high nucleotide identity.
R. A. Edwards, Elizabeth Ann Dinsdale, Anca Mara Segall…·Bhavya Nalagampalli Papudeshi
This study isolates and characterizes three novel Crassvirales phages infecting Bacteroides cellulosilyticus WH2, revealing they do not co-evolve with their hosts and share a conserved tail spike protein involved in host interaction.
Jody C. McKerral, Bhavya Nalagampalli Papudeshi, Laura K. Inglis…·Robert Alan Edwards
The paper quantifies the benefits and costs of prophages in bacterial genomes, showing uniform prophage density and estimating their energetic contribution.