Yi Zhang

This study identifies the taurine-taurine transporter axis as a critical regulator of myeloid leukemia using temporal single-cell RNA-sequencing and functional experiments.

This paper identifies DNA G-quadruplex accumulation as a universal mechanism driving aging across species by impairing epigenetic maintenance and promoting chromatin changes.

This paper introduces EpiTrace, a method using scATAC data to estimate cell age and lineage by analyzing clock-like chromatin accessibility, revealing insights into development and aging.

This study identifies epigenetic reprogramming defects in preeclampsia placenta that cause developmental delay and can be detected in serum cfDNA for early prediction.