Yi Zhang

Epigenomic heterogeneity and spatial organization during human reprogramming

This study examines epigenomic and spatial changes during human reprogramming, finding distinct molecular and spatial patterns in productive versus unsuccessful trajectories.

Integrative multi-omics and multi-trait analysis prioritizes regulatory mechanisms and genes for metabolic dysfunction-associated steatotic liver disease

This study identifies 39 candidate genes involved in MASLD progression using multi-omics and multi-trait analysis, validated through experimental models and an interactive web portal.

Backbone Hydrogen Bonding as a Determinant of Condensate Material States

The paper shows that backbone hydrogen bonding determines condensate material states, as demonstrated by experiments with tetrapeptides and simulations.

Structural Basis of Ligand-Specific Orthosteric-Allosteric Coupling and Sensory Tuning in the Human Bitter Taste Receptor TAS2R14

The paper reports cryo-EM structures of TAS2R14-Gi1 complexes bound to different ligands, revealing TM6 dynamics that govern agonist efficacy and allosteric-orthosteric coupling.

The enhanced multi-tissue atlas of regulatory effects in cattle

The paper presents CattleGTEx, a resource characterizing regulatory effects in cattle, resolving GWAS signals and providing insights into adaptive evolution and selection.

A Single-Cell and Spatial 3D Multi-omic Atlas of Developing Human Basal Ganglia and Inhibitory Neurons

This study creates a 3D multi-omic atlas of developing human basal ganglia and inhibitory neurons, revealing lineage-specific 3D genomic dynamics and regulatory programs associated with neuropsychiatric disease risk.

An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics

The paper reveals an antagonistic epigenetic mechanism in Arabidopsis pollen where MBD5/6 repress methylated loci while MBD7 promotes demethylation and transcriptional activation.

Common and rare variant genetic contributions in African Americans with autism.

This study examines common and rare variant genetic contributions to autism in African Americans, highlighting differences in genetic effects and polygenic score transferability between European and African ancestries.

Structural Definition of Neutralizing Epitopes within and around the HKU1 Receptor-binding Site Reveals Cell Context-Dependent Neutralization

This study identifies mAbs targeting HCoV-HKU1 spike protein and shows that receptor-binding site recognition alone does not predict neutralization in primary cells.

Sediment chemistry controls methane emissions from lake littoral zones

The paper investigates how sediment chemistry, specifically polyphenolic concentration, influences methane emissions from lake littoral zones by altering redox conditions and methanogen composition.

Rhamnose-mediated modulation of hair follicle growth: insights from chemical genomics

This study identifies rhamnose as a compound that promotes hair follicle growth by restoring hair-inducing gene expression and inducing glucose metabolism remodeling.

Constructing a Norm for Children's Scientific Drawing: Distribution Features Based on Semantic Similarity of Large Language Models

This study uses LLMs and semantic similarity to analyze children's scientific drawings, finding consistent representations and identifying factors influencing their drawing accuracy and focus.

Amino Acid-Dependent Material Properties of Tetrapeptide Condensates

This study investigates how different amino acids affect the physical properties of tetrapeptide condensates, revealing significant variations in phase behavior and material properties.

Reconstituting human somitogenesis in vitro

This paper introduces a 3D in vitro model of human somitogenesis using pluripotent stem cells, showing accurate segmentation dynamics and disease relevance.

Discovering and Validating Neoantigens by Mass Spectrometry-based Immunopeptidomics and Deep Learning

This study introduces DeepNovo Peptidome and DeepSelf for neoantigen discovery and validation using immunopeptidomics and deep learning, demonstrating their application in cervical cancer tissues.

Crosstalk in oxygen homeostasis networks: SKN-1/NRF inhibits the HIF-1 hypoxia-inducible factor in Caenorhabditis elegans

The paper identifies crosstalk between SKN-1/NRF and HIF-1 in C. elegans, showing SKN-1 inhibits HIF-1 through EGL-9 regulation.

Hfq Globally Binds and Destabilizes the bound sRNAs and mRNAs in Yersinia pestis

This study maps Hfq-bound RNAs in Yersinia pestis using CLIP-Seq, showing Hfq binds most mRNAs and sRNAs, and facilitates their degradation through base-pairing.

Construction of high-density genetic maps and detection of QTLs associated with Huanglongbing infection in citrus

The paper constructs high-density genetic maps and identifies QTLs associated with Huanglongbing infection in citrus using an intergeneric F1 population.

Mapping and Inheritance analysis of a novel dominant rice male sterility mutant, OsDMS-1

The paper identifies a novel dominant rice male sterility mutant, OsDMS-1, and reports three loci controlling its sterility, conflicting with classical genetic analysis.

The Arabidopsis Auxin F-box proteins AFB4 and AFB5 are Required for Response to the Synthetic Auxin Picloram

This study shows AFB4 and AFB5 function as auxin receptors and are targets of picloram herbicides, with distinct auxin specificity compared to other family members.

Mechanism of β-Aminobutyric Acid-Induced Resistance in Wheat to the Grain Aphid, Sitobion avenae

This study shows that BABA application reduces S. avenae weight and growth, likely due to direct toxicity from high BABA levels in plant phloem, not antifeedant effects.