Marta W. Szulik

This study shows that loss of Smyd5 in cardiomyocytes causes inflammation and heart failure in mice by reducing H4K20me3 and increasing Il-6 expression.

This study functionally characterizes a SMYD1 variant linked to early-onset cardiomyopathy, showing it impairs mitochondrial function and leads to disease.

This study identifies PERM1 as a downstream target of PRDM16 and shows that Perm1 gene therapy improves cardiomyopathy in Prdm16 knockout mice through mitochondrial and sarcomere preservation.