Zhiquan Liu

This study identifies mitochondrial dysfunction and impaired Sonic Hedgehog signaling as key defects in Lowe syndrome, linking OCRL loss to altered neuronal differentiation and ciliary homeostasis.

This paper develops a base editor with CC context-specificity and relaxed PAM recognition to improve precision and targeting scope for gene modification.

This study shows that Prss53 loss in rabbits causes curved hair and skeletal dysplasia, with disrupted calcium metabolism implicated in these phenotypes.