Yang Sun

This study identifies OPTN's role in axonal mitochondria transport and shows its loss contributes to neurodegeneration in models of ALS and NTG.

This study identifies mitochondrial dysfunction and impaired Sonic Hedgehog signaling as key defects in Lowe syndrome, linking OCRL loss to altered neuronal differentiation and ciliary homeostasis.

This paper develops a reversible mouse model of secondary glaucoma using silicone oil and validates it for testing neuroprotective therapies.