Hyung Chul Lee

This study identifies canonical Wnt signaling from the area opaca as essential for inducing and maintaining the marginal zone in pre-primitive-streak chick embryos.

This study identifies new roles for the area opaca in regulating the polarity and positioning of the primitive streak in early chick embryos through experimental embryology.

The paper shows that chick embryo cells use neighborhood-based positional information to position the primitive streak, solving the French Flag Problem.