Cancer BiologybioRxivPreprint
Overcoming treatment resistance mediated by the bone marrow vascular niche in acute myeloid leukemia
Matthew Froid, Sergio Branciamore, Ziang Chen…·David Basanta
This study develops a computational model of the AML bone marrow microenvironment and shows that combining TKIs with miR-126 inhibition can overcome treatment resistance by disrupting the protective vascular niche.
DOI 10.1101/2025.05.22.655592