Author

Bin Zhang

Northwestern UniversityORCID 0000-0002-6631-7647Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Bin Zhang22 papers · Icahn School of Medicine at Mount Sinai

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Catalina Lee-ChangiD· 2 shared Irina V. BalyasnikovaiD· 2 shared Adam M. SonabendiD· 1 shared Aditi Thakur· 1 shared Amy B. HeimbergeriD· 1 shared Andrew GouldiD· 1 shared Craig HorbinskiiD· 1 shared Crismita DmelloiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Catalina Lee-ChangORCID

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3 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedJun 25, 2026

MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, enhances tumor-microglia crosstalk, and drives immune checkpoint blockade efficacy.

Kwang‐Soo Kim, Junyi Zhang, Victor Andrés Arrieta…·Adam M. Sonabend

This study identifies the MAPK/ERK pathway as a key regulator of glioma susceptibility to immune checkpoint blockade, showing it modulates interferon responses, T cell recruitment, and tumor-microglia interactions.

8 citationstop 1%

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ImmunologyJournal for ImmunoTherapy of CancerPeer-reviewedOct 1, 2025

A Bi-Specific T Cell-Engaging Antibody Shows Potent Activity, Specificity, and Tumor Microenvironment Remodeling in Experimental Syngeneic and Genetically Engineered Models of GBM

Μαρκέλλα Ζαννίκου, Joseph T. Duffy, Daniele Procissi…·Irina V. Balyasnikova

This study evaluates a bispecific T cell-engaging antibody in immunocompetent GBM models, showing improved survival, TME remodeling, and immune memory induction.

6 citations

mouseflow cytometry

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Cancer BiologybioRxivPreprintMay 22, 2025

Overcoming treatment resistance mediated by the bone marrow vascular niche in acute myeloid leukemia

Matthew Froid, Sergio Branciamore, Ziang Chen…·David Basanta

This study develops a computational model of the AML bone marrow microenvironment and shows that combining TKIs with miR-126 inhibition can overcome treatment resistance by disrupting the protective vascular niche.

DOI 10.1101/2025.05.22.655592

humanbulk RNA-seq

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