Shang‐Fu Chen

AoUPRS provides a cost-effective PRS calculator for the All of Us dataset, offering both dense and sparse approaches with comparable predictive power.

This paper introduces a denoising autoencoder for rapid, reference-free human genotype imputation, achieving higher accuracy and faster runtime than standard methods.

This study evaluates the impact of coronary artery disease polygenic risk scores on lipid-lowering therapy initiation via a mobile application, finding higher therapy rates among high-risk individuals.