Anika Böttcher

This paper integrates multiple scRNA-seq datasets to create a mouse islet atlas, revealing new insights into β-cell states and differences across diabetes models.

The paper presents a statistical framework for experimental design and power analysis in single cell RNA-seq studies, showing that higher power is achieved with shallow sequencing of more cells per individual.

The paper identifies Wnt/PCP-activated Lgr5+ intestinal stem cells that directly differentiate into enteroendocrine or Paneth cells, challenging previous models of multipotency.