Sophie Tritschler

This study identifies Synaptotagmin 13 as a key regulator of endocrine cell egression and islet formation through its role in cell polarity and basement membrane remodeling.

Sfaira provides a data and model zoo for single-cell RNA-seq, enabling fast reuse of pre-trained models and datasets across human and mouse tissues.

The paper identifies Wnt/PCP-activated Lgr5+ intestinal stem cells that directly differentiate into enteroendocrine or Paneth cells, challenging previous models of multipotency.