Cancer BiologyMolecular Cancer TherapeuticsPeer-reviewed
Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors
Kyle Brandon Williams, Alex T. Larsson, Bryant J. Keller…·David A. Largaespada
This study identifies 23 compounds that selectively kill NF1-deficient Schwann cells and shows their efficacy in vivo, with synergy when combined with Selumetinib.
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