Purinergic receptor P2RY14 cAMP signaling regulates EGFR-driven Schwann cell precursor self-renewal and nerve tumor initiation in neurofibromatosis.
Jennifer Patritti Cram, Jianqiang Wu, Shinji Kuninaka, Robert A. Coover, Robert F. Hennigan, Tilat A. Rizvi, Katherine E. Chaney, Ramya Ravindran, Jose A. Cancelas, Robert J. Spinner, Nancy Ratner
This study identifies P2RY14 as a regulator of cAMP signaling in Schwann cell precursors, showing its role in self-renewal and neurofibroma initiation in NF1 mutant cells.
eLife · Mar 21, 2022Peer-reviewedNeuroscience