Author

Guibin Chen

National Institutes of HealthORCID 0000-0001-5520-1780Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Manfred BoehmiD· 2 shared Adriana A. de JesusiD· 1 shared André LarochelleiD· 1 shared Andre T. RastegariD· 1 shared Angélique BiancottoiD· 1 shared Anna Huttenlocher AiD· 1 shared Bernadette Marrero· 1 shared Cameron Manes· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Manfred BoehmORCID

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2 papers

Recent·Most cited

Genetic & Genomic MedicineNature CommunicationsPeer-reviewedMar 17, 2023

Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome

Adriana A. de Jesus, Guibin Chen, Dan Yang…·Raphaela T. Goldbach‐Mansky

This study identifies de novo LYN variants causing constitutive Lyn kinase activation, leading to neutrophilic vasculitis and liver fibrosis, and shows therapeutic response to Src kinase inhibitors.

37 citationstop 5%

humanstatistical model

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Developmental BiologyStem Cell ResearchPeer-reviewedOct 15, 2019

Robust generation of erythroid and multilineage hematopoietic progenitors from human iPSCs using a scalable monolayer culture system

Juan Pablo Ruíz, Guibin Chen, Juan J. Haro‐Mora…·André Larochelle

This study develops a scalable monolayer culture system for generating erythroid and multilineage hematopoietic progenitors from human iPSCs, showing limited HSC engraftment potential.

41 citations

humanbulk RNA-seq

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