Author

Adriana A. de Jesus

National Institutes of HealthORCID 0000-0001-8966-8362Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Raphaela T. Goldbach‐ManskyiD· 3 shared Dan YangiD· 2 shared Farzana BhuyaniD· 2 shared Manfred BoehmiD· 2 shared Sara AlehashemiiD· 2 shared Adam Reinhardt· 1 shared Adam X. MirandaiD· 1 shared Alberto IannuzzoiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCell Biology

Raphaela T. Goldbach‐ManskyORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintMar 24, 2026

STING-STAT3-SOX18 Axis Drives EndMT and Epigenetic Reprogramming in SAVI Lung Fibrosis

Dan Yang, Guibin Chen, Sachin Gaurav…·Raphaela T. Goldbach‐Mansky

This study identifies a STING-STAT3-SOX18 axis driving EndMT and epigenetic reprogramming in SAVI lung fibrosis, suggesting STING as a therapeutic target.

DOI 10.64898/2026.03.23.713256

humanbulk RNA-seq

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ImmunologyNature CommunicationsPeer-reviewedNov 16, 2024

Autoinflammatory patients with Golgi-trapped CDC42 exhibit intracellular trafficking defects leading to STING hyperactivation

Alberto Iannuzzo, Selket Delafontaine, Rana El Masri…·Jérôme Delon

This study identifies Golgi-trapped CDC42 variants causing STING hyperactivation and IFN elevation in autoinflammatory patients.

14 citations

humanproteomics

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Genetic & Genomic MedicineNature CommunicationsPeer-reviewedMar 17, 2023

Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome

Adriana A. de Jesus, Guibin Chen, Dan Yang…·Raphaela T. Goldbach‐Mansky

This study identifies de novo LYN variants causing constitutive Lyn kinase activation, leading to neutrophilic vasculitis and liver fibrosis, and shows therapeutic response to Src kinase inhibitors.

37 citationstop 5%

humanstatistical model

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