MicrobiologybioRxivPreprint
SpiE is a distinct gut microbial 4-cholesten-3-one 5β-reductase that acts with SpiR to convert cholesterol to coprostanol
Angela K Jiang, Gabriela Arp, Margaret Kato…·Xiaofang Jiang
The paper identifies SpiE as a gut microbial enzyme that, along with SpiR, converts cholesterol to coprostanol, and shows its correlation with stool coprostanol levels and antibiotic impact.
DOI 10.64898/2026.10.06.757028