Author

Alexandra M. Clarke

University of Maryland, College Park

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:metagenomics· 2 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Andrew Brantley HalliD· 2 shared Angela K JiangiD· 2 shared Gabriela ArpiD· 2 shared Maggie R. GrantiD· 2 shared Xiaofang JiangiD· 2 shared Yue Li· 2 shared Alan K. JarmuschiD· 1 shared Ashley M. SidebottomiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersMicrobiology

Andrew Brantley HallORCID

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2 papers

Recent·Most cited

SpiE is a distinct gut microbial 4-cholesten-3-one 5β-reductase that acts with SpiR to convert cholesterol to coprostanol

Angela K Jiang, Gabriela Arp, Margaret Kato, Tess Brunner, Maggie R. Grant, Alexandra M. Clarke, Ashley M. Sidebottom, Mary McMillin, Christopher J. Lehmann, Matthew August Odenwald, Krysta S. Wolfe, Bhakti Patel, Olatoyosi M. Odenike, Yue Li, Samuel H. Light, , Xiaofang Jiang

The paper identifies SpiE as a gut microbial enzyme that, along with SpiR, converts cholesterol to coprostanol, and shows its correlation with stool coprostanol levels and antibiotic impact.

bioRxiv · Oct 8, 2026 · PreprintMicrobiology

Discovery of BilV reveals a multienzymatic basis for bilirubin reduction across vertebrate gut microbiomes

Angela K Jiang, Maggie R. Grant, Gabriela Arp, Keith Dufault‐Thompson, Alexandra M. Clarke, Yue Li, Danielle A. Lehman, Alan K. Jarmusch, Brantley Hall, Xiaofang Jiang

The paper identifies BilV, a novel enzyme that works with BilR to reduce bilirubin to urobilinogen, and shows its distribution varies across vertebrate gut microbiomes.

bioRxiv · Jun 2, 2026 · PreprintMicrobiology