Author

Christopher J. Lehmann

University of ChicagoORCID 0000-0002-1111-2169Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:comparative / phylogenetic analysis· 1 Research Focus:dimensionality reduction· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:metagenomics· 1

Frequent Co-Authors

Ashley M. SidebottomiD· 2 shared Mary McMilliniD· 2 shared Matthew August OdenwaldiD· 2 shared Alexandra M. Clarke· 1 shared Amber R. RoseiD· 1 shared Andrew Brantley HalliD· 1 shared Angela K JiangiD· 1 shared Angelica MoraniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

Ashley M. SidebottomORCID

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Author profile →

2 papers

Recent·Most cited

SpiE is a distinct gut microbial 4-cholesten-3-one 5β-reductase that acts with SpiR to convert cholesterol to coprostanol

Angela K Jiang, Gabriela Arp, Margaret Kato, Tess Brunner, Maggie R. Grant, Alexandra M. Clarke, Ashley M. Sidebottom, Mary McMillin, Christopher J. Lehmann, Matthew August Odenwald, Krysta S. Wolfe, Bhakti Patel, Olatoyosi M. Odenike, Yue Li, Samuel H. Light, , Xiaofang Jiang

The paper identifies SpiE as a gut microbial enzyme that, along with SpiR, converts cholesterol to coprostanol, and shows its correlation with stool coprostanol levels and antibiotic impact.

bioRxiv · Oct 8, 2026 · PreprintMicrobiology

Fecal Metabolite Quantitation for Rapid Assessment of the Gut Microbiome

Michael W. Mullowney, Angelica Moran, Antonio Hernandez, Mary McMillin, Amber R. Rose, David Moran, Jessica Little, Ann B. Nguyen, Bhakti K. Patel, Christopher J. Lehmann, Matthew August Odenwald, Eric G. Pamer, Kiang-Teck J Yeo, Ashley M. Sidebottom

This paper presents a rapid diagnostic test to measure fecal butyrate and deoxycholic acid concentrations as markers of microbiome function, enabling quick identification of patients with microbiome deficiencies.

PLoS ONE · Jan 9, 2026Peer-reviewedPathology