BiophysicsbioRxivPreprint
Protein entanglement misfolding determines divergent fates: proteasomal degradation or persistence in near-native misfolded states
Yang Jiang, Anushka Jain, Sina Ghaemmaghami, Edward P. O’Brien
The paper investigates how protein entanglement misfolding affects proteasomal degradation in human cells, finding that entangled proteins are more likely to be ubiquitinated and degraded.
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