Author
Pennsylvania State UniversityORCID 0000-0003-1100-9177Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Yang Jiang, Anushka Jain, Sina Ghaemmaghami, Edward P. O’Brien
The paper investigates how protein entanglement misfolding affects proteasomal degradation in human cells, finding that entangled proteins are more likely to be ubiquitinated and degraded.
Ian M. Sitarik, Yang Jiang, Hyebin Song, Edward P. O’Brien
The paper introduces EntDetect, a tool to detect non-covalent lasso entanglements in protein structures, simulations, and mass spectrometry data, and demonstrates its application in identifying misfolded states.
Yingzi Xia, Barbara T. Amann, Richard E. Gillilan…·Stephen D. Fried
This study identifies a topologically misfolded form of E. coli phosphoglycerate kinase that is more stable than its native state and resists denaturation.