Maturation stage-specific V-ATPase disassembly can explain neutral pH of lysosome-related organelles
Ajay Pradhan, Niraj Nivas Tadasare, Debolina Sarkar, Vandna Maurya, Lavan K. Bansal, Aaron P. Turkewitz, Santosh Kumar
The paper shows that mature lysosome-related organelles in Tetrahymena thermophila are non-acidic due to V-ATPase disassembly, while immature ones are acidified.
bioRxiv · Jan 13, 2025 · PreprintCell Biology