Aaron P. Turkewitz

This paper introduces Tet Trim-Away, a system for rapid protein degradation in Tetrahymena thermophila, enabling acute depletion and loss-of-function phenotypes.

The paper consolidates RNA-seq and microarray data to infer gene-pathway associations in Tetrahymena thermophila, identifying known and novel functionally related genes through co-expression clustering.

The paper shows that mature lysosome-related organelles in Tetrahymena thermophila are non-acidic due to V-ATPase disassembly, while immature ones are acidified.

The paper introduces CDH, a tool that automates gene annotation and co-regulation analysis in Tetrahymena thermophila, expanding pathway insights through ortholog function inference.