Author

Giacomo Frati

InsermORCID 0000-0001-5584-6060Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Annarita MiccioiD· 1 shared Anne ChalumeauiD· 1 shared Bochra Mlayah· 1 shared Giandomenico TurchianoiD· 1 shared Gilles Sartre· 1 shared Giulia HardouiniD· 1 shared Jean‐Paul ConcordetiD· 1 shared Mégane BrussoniD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioengineering

Annarita MiccioORCID

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1 paper

Recent·Most cited

BioengineeringMolecular TherapyPeer-reviewedJul 22, 2024

Safety and efficacy study of CRISPR/Cas9 treatment of sickle cell disease in clinically relevant conditions highlights disease-specific response

Giacomo Frati, Mégane Brusson, Gilles Sartre…·Annarita Miccio

This study evaluates the safety and efficacy of CRISPR/Cas9-mediated HbF reactivation in sickle cell disease by testing it in patient-derived HSPCs and shows it is effective but has off-target effects.

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humangenetic perturbation / CRISPR

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