Author

Jai Krishan Khurana

Harvard UniversityORCID 0000-0001-5664-2764Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1 Assay:metagenomics· 1

Frequent Co-Authors

Emily P. BalskusiD· 2 shared Antonio TinocoiD· 1 shared Bryan Banuelos JaraiD· 1 shared C. Anders OlsoniD· 1 shared Chenhao LiiD· 1 shared Chi "Chip" LeiD· 1 shared Damian Rafal PlichtaiD· 1 shared Douglas J. KennyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

Emily P. BalskusORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 3, 2026

Inhibitors of gut bacterial L-dopa decarboxylation with reduced susceptibility to host metabolism

Rohan Narayan, Chi "Chip" Le, Jai Krishan Khurana…·Emily P. Balskus

This paper develops AFMT analogs that inhibit gut bacterial L-dopa decarboxylases while reducing susceptibility to host metabolism.

DOI 10.64898/2026.04.08.717077

humanexperimental assay

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BiochemistrybioRxivPreprintDec 30, 2025

Discovery of the metalloenzyme IsmB revises a pathway for coprostanol formation by the human gut microbiome

Antonio Tinoco, Chenhao Li, Jai Krishan Khurana…·Emily P. Balskus

This study identifies and characterizes the IsmB enzyme, which catalyzes a key step in coprostanol formation by the human gut microbiome, and links its presence to lower serum cholesterol levels.

1 citation

humanmetagenomics

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