Author

Yu Ishimoto

National Institute of Diabetes and Digestive and Kidney DiseasesORCID 0000-0001-5773-8637Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Fang ZhouiD· 2 shared Gregory George GerminoiD· 2 shared Luís F. MenezesiD· 2 shared Cheng-Chao Lin· 1 shared David Eric AndersoniD· 1 shared Elisabeth Pearson· 1 shared Jeff M. ReeceiD· 1 shared Karla Barbosa-SabaneroiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetics

Fang ZhouORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintFeb 17, 2026

Studies of mice with a large deletion of the ARPKD-associated Pkhd1 locus likely explain its GWAS association with glaucoma in humans

Yu Ishimoto, Luís F. Menezes, Nakaya Naoki…·Gregory George Germino

The paper shows that a Pkhd1 deletion in mice causes glaucoma by disrupting Tfap2b expression, linking PKHD1 SNPs to human glaucoma.

DOI 10.64898/2026.02.15.706040

mousestatistical model

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GeneticsbioRxivPreprintApr 8, 2022

Use of a novel knock-in allele of Pkd1 identifies nicotinamide nucleotide dehydrogenase as a mitochondrial binding partner of polycystin-1

Cheng-Chao Lin, Luís F. Menezes, Elisabeth Pearson…·Gregory George Germino

The paper generates a new mouse model to study Polycystin-1's mitochondrial localization and function, identifying Nnt as a binding partner and showing NAC treatment benefits in Nnt+/+ mice.

DOI 10.1101/2022.04.08.487705

mouseproteomics

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