Author

Gregory George Germino

National Institutes of HealthORCID 0000-0002-3609-5588Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Fang ZhouiD· 3 shared Luís F. MenezesiD· 3 shared Yu IshimotoiD· 2 shared Cheng-Chao Lin· 1 shared David Eric AndersoniD· 1 shared Elisabeth Pearson· 1 shared Hongyi CaiiD· 1 shared Hugo Martin Garraffo· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenetics

Fang ZhouORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintFeb 17, 2026

Studies of mice with a large deletion of the ARPKD-associated Pkhd1 locus likely explain its GWAS association with glaucoma in humans

Yu Ishimoto, Luís F. Menezes, Nakaya Naoki…·Gregory George Germino

The paper shows that a Pkhd1 deletion in mice causes glaucoma by disrupting Tfap2b expression, linking PKHD1 SNPs to human glaucoma.

DOI 10.64898/2026.02.15.706040

mousestatistical model

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GeneticsbioRxivPreprintApr 8, 2022

Use of a novel knock-in allele of Pkd1 identifies nicotinamide nucleotide dehydrogenase as a mitochondrial binding partner of polycystin-1

Cheng-Chao Lin, Luís F. Menezes, Elisabeth Pearson…·Gregory George Germino

The paper generates a new mouse model to study Polycystin-1's mitochondrial localization and function, identifying Nnt as a binding partner and showing NAC treatment benefits in Nnt+/+ mice.

DOI 10.1101/2022.04.08.487705

mouseproteomics

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GeneticsKidney360Peer-reviewedJul 16, 2021

Pkd1 mutation has no apparent effects on peroxisome structure or lipid metabolism

Takeshi Terabayashi, Luís F. Menezes, Fang Zhou…·Gregory George Germino

This study investigates whether Pkd1 mutation affects peroxisome structure or lipid metabolism in ADPKD models, finding no significant disruptions in peroxisome biogenesis or fatty acid metabolism.

2 citations

mousebulk RNA-seq

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