The paper investigates genetic and causal links between post-traumatic stress disorder and rapid-eye-movement sleep behavior disorder using polygenic risk scores, genetic correlation, and Mendelian randomization analyses.

medRxiv · Sep 5, 2025 · PreprintGenetic & Genomic Medicine

Lack of Epistatic Interaction of SNCA with APOE in Synucleinopathies

Prabhjyot Saini, Eric Yu, Mehrdad A. Estiar, Lynne Krohn, Kheireddin Mufti, Uladzislau Rudakou, Jennifer A. Ruskey, Farnaz Asayesh, Sandra B. Laurent, Dan Spiegelman, Isabelle Arnulf, Jacques Yves Montplaisir, Jean‐François Gagnon, Alex Désautels, Yves A Dauvilliers, , Ziv Gan‐Or

The paper investigates genetic interactions between SNCA and APOE in synucleinopathies using GWAS data and finds no significant epistatic interactions after multiple testing correction.

Brain Communications · Jan 1, 2025Peer-reviewedGenetic & Genomic Medicine

NPC1 variants are not associated with Parkinson's disease, REM-sleep behaviour disorder or Dementia with Lewy bodies in European cohorts.

Emma N. Somerville, Lynne Krohn, Eric Yu, Uladzislau Rudakou, Konstantin A. Senkevich, Jennifer A. Ruskey, Farnaz Asayesh, Jamil Ahmad, Dan Spiegelman, Yves A Dauvilliers, Isabelle Arnulf, Michele T.M. Hu, Jacques Yves Montplaisir, Jean‐François Gagnon, Alex Désautels, , Ziv Gan‐Or

This study examines the association of NPC1 variants with Parkinson's disease, REM-sleep behavior disorder, and dementia with Lewy bodies in European cohorts and finds no significant associations.

medRxiv · Nov 8, 2022 · PreprintGenetic & Genomic Medicine

Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects

Lynne Krohn, Karl Heilbron, Cornelis Blauwendraat, Regina Hertfelder Reynolds, Eric Yu, Konstantin A. Senkevich, Uladzislau Rudakou, Mehrdad A. Estiar, Emil Karl Gustavsson, Kajsa Atterling Brolin, Jennifer A. Ruskey, Kathryn Freeman, Farnaz Asayesh, Ruth Chia, Isabelle Arnulf, , Ziv Gan‐Or

This study identifies five RBD risk loci through genome-wide association and finds differential expression of SNCA-AS1 and SCARB2 in brain regions.

medRxiv · Sep 8, 2021 · PreprintGenetic & Genomic Medicine

GBA variants in REM sleep behavior disorder: a multicenter study

Lynne Krohn, Jennifer A. Ruskey, Uladzislau Rudakou, Etienne Léveillé, Farnaz Asayesh, Michele T.M. Hu, Isabelle Arnulf, Yves A Dauvilliers, Birgit Högl, Ambra Stefani, Christelle Charley Monaca, Beatriz Abril, Giuseppe Plazzi, Elena Antelmi, Luigi Ferini‐Strambi, , Ziv Gan‐Or

This study investigates the association between GBA variants and risk for isolated REM sleep behavior disorder (iRBD) and conversion to neurodegeneration, finding higher prevalence and increased conversion rates in carriers.

Neurology · Jun 27, 2020Peer-reviewedGenetic & Genomic Medicine

Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies

Lynne Krohn, Richard Y. J. Wu, Karl Heilbron, Jennifer A. Ruskey, Sandra B. Laurent, Cornelis Blauwendraat, Armaghan Alam, Isabelle Arnulf, Michele T.M. Hu, Yves A Dauvilliers, Birgit Högl, Mathias Toft, Kari Anne Bjørnarå, Ambra Stefani, Evi Holzknecht, , Ziv Gan‐Or

This study identifies SNCA risk variants specific to RBD and overt synucleinopathies, finding distinct associations and opposite effects at the 3' end of SNCA.

Annals of Neurology · Jan 24, 2020Peer-reviewedGenetics

Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire

Hanna Maria Ollila, Eilon Sharon, Ling Lin, Nasa Sinnott-Armstrong, Aditya Ambati, Ryan P. Hillary, Otto Jolanki, Juliette H. Faraco, Mali A. Einen, Guo Luo, Jing Zhang, Fang Han, Han Yan, Xiao Song Dong, Jing Li, , Emmanuel Jean-Marie Mignot

This study identifies genetic risk loci for narcolepsy, showing enrichment in immune cells and suggesting autoimmune modulation via T cell receptor chains and influenza-A infection.

bioRxiv · Jul 22, 2018 · PreprintGenetics