Hanna Maria Ollila

GWAS of Lyme disease identifies five loci and discovers a connection with post-infectious diseases

This study conducts a GWAS of Lyme disease, identifying five genetic loci and linking it to post-infectious diseases like Bell palsy and joint pain.

The genetic architecture of fibromyalgia across 2.5 million individuals

This study identifies 26 risk loci for fibromyalgia through a genome-wide association analysis of 2.5 million individuals, revealing genetic links to neural functions and chronic pain disorders.

Population-scale molecular reconstruction of human circadian phase from blood biomarkers

The paper infers circadian phase from blood biomarkers in UK Biobank using machine learning and defines a new construct, circadian acceleration, with genetic and environmental associations.

Rare Coding Variants Reveal Distinct Genetic Architectures Across Multidimensional Sleep Phenotypes

The paper identifies 260 genes associated with sleep phenotypes using rare coding variants from large-scale sequencing data, revealing distinct genetic architectures and biological mechanisms across different sleep measurements.

Genetic architecture of 67 oral diseases and their links to systemic diseases

This study identifies 105 genetic loci associated with 67 oral diseases and finds strong genetic correlations between oral and systemic conditions.

Genetic variants affect diurnal glucose levels throughout the day

The paper identifies genetic variants associated with diurnal glucose levels and their role in type 2 diabetes risk.

Meta-analysis of Cannabis Use Identifies Shared Genetic Loci with Sleep and Circadian Rhythms

This study identifies 39 genetic loci shared between cannabis use and sleep traits through a meta-analysis of 152,807 cases and 220,272 controls.

Genome-wide association meta-analyses over one million individuals identify 54 loci associated with urinary incontinence and its subtypes

Genome-Wide Meta-Analysis Identifies Genetic Risk Loci for Mono- and Polyneuropathies in 983,477 Individuals

This study identifies 48 genetic loci and 66 fine-mapped signals associated with mono- and polyneuropathies using GWAS and meta-analysis across 983,477 individuals.

Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry

This study identifies a genetic association between thromboembolism risk and long COVID in individuals of European ancestry, suggesting thromboembolism as a potential contributor to long COVID pathogenesis.

From Normal Variation in Sleep to Clinical Sleep Disorders: Genetic Insights from Over One Million Individuals

This study identifies genetic associations for multiple sleep disorders and medications in over 1.6 million individuals, revealing shared and unique genetic factors across sleep traits.

Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome

This study conducts a genome-wide association study (GWAS) of ME/CFS, identifying eight genetic loci associated with the disease, suggesting involvement of immune and neurological processes.

Haplotype Analysis Reveals Pleiotropic Disease Associations in the HLA Region

This study uses haplotype analysis to identify disease associations in the HLA region across 412,181 Finnish individuals, revealing pleiotropic patterns and 7,649 associations across 647 traits.

An integrative approach prioritizes the orphan GPR61 genomic region in tissue-specific regulation of chronotype

This study identifies a genetic correlation between chronotype and ease of getting-up, prioritizing the GPR61 locus and variant rs12044778 through colocalization and functional analysis.

Leveraging nationwide health care records in Estonia to identify the genetic background of understudied disease phenotypes

The paper uses Estonian Biobank data to identify genetic loci associated with 5,491 disease phenotypes, finding 3,222 genome-wide significant loci and 754 protein-altering variant-trait associations.

Regulatory variation at serotonin receptor 1F (HTR1F) modulates arousals and risk for sleep apnea

The paper identifies regulatory variation at HTR1F associated with sleep apnea risk and arousals, particularly in non-obese individuals.

Image-based profiling of healthy donor immune cells with Blood Cell Painting reveals novel genotype-phenotype associations

The paper develops Blood Cell Painting (BCP) to profile immune cell morphology in healthy donors, identifying genetic and clinical associations with immune cell features.

The alpha-2A-adrenergic receptor (ADRA2A) modulates susceptibility to Raynaud's syndrome

This study identifies ADRA2A as a major risk locus for Raynaud's syndrome through genome-wide association analysis and functional validation in vascular smooth muscle cells.

A FinnGen pilot clinical recall study for Alzheimer's disease

The paper demonstrates the feasibility of conducting clinical recall studies from the FinnGen biobank to collect customized clinical data from participants with Alzheimer's disease or mild cognitive disorder.

Multi-ancestry genome-wide analysis identifies common genetic variants for self-reported sleep duration and shared genetic effects

The paper identifies common genetic variants for sleep duration across multiple ancestries and finds shared genetic effects in diverse populations.

Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection

This study identifies genetic drivers and cellular selection signatures of mosaic X chromosome loss in women using large-scale population data and polygenic scores.

The impact of Mendelian sleep and circadian genetic variants in a population setting

This study examines the impact of Mendelian sleep and circadian genetic variants in population cohorts and finds no strong associations with extreme sleep traits, though some variants show minor effects.

Genetic risk factors have a substantial impact on healthy life years

This study estimates the impact of genetic risk factors on disease burden using disability-adjusted life years (DALYs) and finds that both common and rare variants significantly contribute to healthy life years lost.

Large Registry Based Analysis of Genetic Predisposition to Tuberculosis Identifies Genetic Risk Factors at HLA

The paper identifies genetic risk factors for tuberculosis, including HLA alleles and INPP5A variants, and shows smoking as a lifestyle risk factor.

Secretoglobin family 1D member 2 (SCGB1D2) protein inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease

The paper identifies a genetic variant in SCGB1D2 that increases Lyme disease susceptibility and shows that the wild-type protein inhibits Borrelia burgdorferi growth more effectively than the variant.

BMAL1 loss in oligodendroglial lineage cells dysregulates myelination and sleep

The paper shows BMAL1 regulates oligodendroglial maintenance and myelination, which affects sleep, and links this to MS pathology.

Genomic and transcriptomic data analyses highlight KPNB1 and MYL4 as novel risk genes for congenital heart disease

The paper identifies KPNB1 and MYL4 as novel risk genes for congenital heart disease through GWAS, eQTL analysis, and functional validation in patient-derived cardiomyocytes.

Kleine Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci.

This study identifies a genetic association between Kleine-Levin Syndrome and variants in the TRANK1 gene, with increased risk linked to birth difficulties.

Genetic determinants of daytime napping and effects on cardiometabolic health

This study identifies genetic loci associated with daytime napping and finds potential causal links between napping and cardiometabolic traits.

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health

This study identifies five genetic loci associated with obstructive sleep apnoea and finds a causal link between BMI and OSA through polygenic risk scores and Mendelian randomization.